PHOTOBIOLOGY STUDIES

Manager L. Duteil

 

1. Solar protection

  • ž   SPF (COLIPA, ISO 24444:2010), IP PUVA
  • ž   Drug phototoxicity protection
  • ž   Immune response protection
  • ž   Melasma protection
  • ž   Light-eruption protection (BSLE …)

 

2. Photo induction

  • ž   UV-induced inflammation
  • ž   Post UVA/UVB xerosis
  • ž   UV-induced pigmentation (tanning, post-inflammatory pigmentation)
  • ž   Photo-induced damage (cellular, mediators, ROS, MMP, cytokines …)

 

3. Models

  • ž   Evaluation of depigmenting agents
  • ž   Evaluation of anti-aging agents (anti-photoaging)
  • ž   Post-inflammatory pigmentation, UV and visible light

 

4. Others

  • ž   Use test (beach, mountain)
  • ž   Natural sun, controlled exposure tests
  • ž   Regulatory Phase I tests (phototoxicity, photosensitization)

 

MATERIaL

Oriel 1600W solar simulators

  • ž   UV spectrum
  • ž   Visible light spectrum

Waldmann UV 180 tubes for UVB only exposure

 

TESTS UNDER REAL CONDITIONS (OUTDOOR)

  • ž   March-September: Performed in Nice (sunshine>200h/month), seaside
  • ž   October-March: Performed overseas (West Indies)